The peer-reviewed evidence behind REMS
REMS is not a new or experimental technique. It has been studied in peer-reviewed medical journals for years — on fracture prediction, bone quality, and how it compares with DEXA. We've collected the key publications here so you and your physician can read the evidence directly.
Fracture risk, not just density
Multiple studies show the Fragility Score predicts fractures more accurately than bone density alone.
Accuracy where DEXA struggles
Research in arthritis and rheumatoid patients shows REMS filters out distortions that mislead DEXA.
Validated in large populations
Multicenter trials established REMS diagnostic reliability across many sites and operators.
Eight studies worth reading
Each opens the full published paper. They are grouped below in the order we suggest reading them.
REMS for the prediction of incident fragility fractures
Examines how well REMS predicts fragility fractures compared with bone density measurement alone — a key study behind the Fragility Score's use in estimating 5-year fracture risk.
Adami et al.
Journal of Bone and Mineral Research
Read the summaryREMS for bone strength assessment
A position paper from the European Society for Clinical and Economic Aspects of Osteoporosis reviewing what REMS measures and where it fits in bone strength assessment.
Diez-Perez et al.
ACER — ESCEO Working Group
Read the summaryREMS in patients with rheumatoid arthritis
Studies REMS use in rheumatoid arthritis patients, a group where calcium buildup and joint changes make DEXA readings harder to interpret accurately.
Bojincă et al.
Experimental and Therapeutic Medicine
Read the summaryREMS and DXA in a peritoneal dialysis setting
Compares REMS with DXA in dialysis patients, a group where artery calcification can distort standard DXA readings — and finds REMS resistant to that artifact.
Fassio et al.
Aging Clinical and Experimental Research
Read the summaryFragility Score: a five-year longitudinal study
A five-year follow-up tracking the Fragility Score's ability to forecast fractures over time — the strongest published evidence for its 5-year risk estimate.
Pisani et al.
Aging Clinical and Experimental Research
Read the summaryREMS in pre- and post-menopausal women
Assesses REMS in women before and after menopause — the population with the fastest bone loss, and the group most often advised to avoid repeat radiation exposure.
Kirilova et al.
Clinical Cases in Mineral and Bone Metabolism
Read the summaryA Polish review of REMS technology
A clinical review of REMS from a rheumatology perspective — how the technology works, what it reports, and how rheumatologists can use it in practice.
Iwaszkiewicz & Leszczyński
Forum Reumatologiczne
Read the summaryThe REMS multicenter clinical trial
The large multicenter trial establishing REMS accuracy against DEXA across many sites and operators — foundational evidence for the technology's diagnostic reliability.
Di Paola et al.
Osteoporosis International
Read the summaryThese papers are published by their respective journals and hosted here for reference. They are provided for education — your physician is the right person to interpret them for your situation.
What this research means for your scan
You don't need to read the studies to benefit from them. The findings shape what your report contains — and what you and your physician can do with it.
- Your report includes a Fragility Score, the measure these studies show predicts fracture risk more accurately than density alone.
- Your scan involves no radiation, so it can be repeated for monitoring as often as your physician recommends.
- Your results are not distorted by arthritis or calcium buildup the way a DEXA reading can be.
- Your physician receives measurements they can compare against published benchmarks.
Where to start reading
If you only have time for two papers, start with these:
- 01
The multicenter trial
Establishes that REMS is accurate across many sites and operators. The foundation everything else builds on.
- 02
The 5-year Fragility Score study
Tracks fracture prediction over five years — the clearest evidence for what your Fragility Score means.
Have a question about any of these papers? Call us and we'll walk you through what they found.
The evidence is clear. The next step is yours.
About 15 minutes, no radiation, and a report grounded in published research. Serving patients across New York and New Jersey.